Hierarchical Structure-Based Virtual Screening for Drug Design
Maria A. Miteva · Biotechnology & Biotechnological Equipment · 2008
Virtual ligand screening (VLS) has become an established approach for identification of new hit compounds for drug discovery programs. Recently hierarchical structure-based VLS (SB-VLS) protocols consisting of different levels of filtering have been developed. It was demonstrated that such hierarchical procedures based on docking-scoring methodology significantly improve the speed and the quality of SB-VLS. Here we overview current SB-VLS methods and hierarchical VLS protocols. Finally we present recent success stories obtained with hierarchical VLS methods.