Statistical analysis of data from single molecule experiment
Tomasz Burzykowski, Jacek Piotr Szubiakowski, Tobias Rydèn · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · 2003
The maximum-likelihood estimation method is considered. It is based on three-level Dehmelt scheme of isolated quantum system and it makes use of the theory of Markov-modulated Poison process. This method is applied to the analysis of the photon-counting distribution resulting from a single molecule fluorescence experiment. It is assumed that the data available for the estimation contain only the number of collected photons per time interval.