SU‐E‐J‐89: Deformable Registration Method Using B‐TPS in Radiotherapy
Yaoqin Xie · Medical Physics · 2012
PURPOSE: A novel deformable registration method for four-dimensional computed tomography (4DCT) images is developed in radiation therapy. METHODS: The proposed method combines the thin plate spline (TPS) and B-spline together to achieve high accuracy and high efficiency. The method consists of two steps. First, TPS is used as a global registration method to deform large unfit regions in the moving image to match counterpart in the reference image. Then B-spline is used for local registration, the previous deformed moving image is further deformed to match the reference image more accurately. RESULTS: Two clinical CT image sets, including one pair of lung and one pair of liver, are simulated using the proposed algorithm, which results in a tremendous improvement in both run-time and registration quality, compared with the conventional methods solely using either TPS or B-spline. CONCLUSIONS: The proposed method can combine the efficiency of TPS and the accuracy of B-spline, performing good adaptively and robust in registration of clinical 4DCT image.