Discovery Strategies in a BioPharmaceutical Startup: Maximising your Chances of Success Using Computational Filters
Andrew J. Jennings, Mike Tennant · Current Pharmaceutical Design · 2005
Small research-based pharmaceutical start-ups often lack the budget and do not have the infrastructure available to apply all possible techniques for compound selection. This review details our use of a range of techniques such as high-throughput docking and similarity searching to maximize the success rate when attempting to identify pharmaceutically relevant ligands in a resource-constrained environment. Keywords: docking methods, murein synthetic pathway, enzymes, murb assay, diversity metrics, pharmacophore