Importance of Amino Acid Side Groups for Biologic Activity of Angiotensin II
F. Merlin Bumpus, Robert R. Smeby · Circulation · 1962
The requirements for biologic activity of angiotensin II may be summarized from available data as follows: (1) a free C-terminal carboxyl group, (2) a phenyl group as a side group of amino acid number 8, (3) a phenolic group on amino acid number 4, (4) proline in position 7, (5) possibly a definite degree of spatial order, (6) at least 6 amino acids from the C-terminus, (7) possibly the imidazole of histidine in position 6.