Bioinformatic Networks: Molecular Reticles for Pinpointing Pharmacological Target Selection
Randolph S. Faustino, André Terzic · Clinical Pharmacology & Therapeutics · 2008
Bridging centrality was developed as a novel metric to capitalize on rich biological networks and enable selection of therapeutically efficient, druggable candidates. Through incorporation of local and global network properties, targetable nodes are identified that harbor latent capacity to intercept informational flow without compromising systemic functionality. Translational implementation holds potential for increased therapeutic specificity and offers opportunities to add value to drug discovery and development through facilitation of individualized treatment.