Structure Activity Relationship (SAR) Studies on the Tricyclic Antidepressor Compounds Marketed in Turkey. II
Ningur Noyanalpan · Ankara Universitesi Eczacilik Fakultesi Dergisi · 1978
In this research structure activity relationship of tricyclic antidepressor compounds have been studied using log P and R M After determining the partition coefficients and log P values they have been plotted versus LD„ values reported in literature and graphs have been constructed. On the graph thus obtained there are two lines of correlation. Six compounds build one of the correlation lines and four build the other. Also correlation equations have been derived after constructing the correlation tables. The equations have good r values and small s values. A series of tic studies has shown that a similar correlation can also be produced on tic plates with a poorer precision. Also the equations derived thereof have smaller r values and larger s values. Looking at the results obtained with log P vs. LD„ plotting and several R1 vs. LD„ plotting one can bring some comments on the variances in reports about the ',D si, values of these compounds.