The use of topological indexes to predict theRMvalues of higher fatty acids, hydroxy fatty acids, and their esters in RPTLC
Anna Niestrój, Alina Pyka, Józef S̀liwiok · Journal of Planar Chromatography – Modern TLC · 2002
Higher fatty acids and hydroxy fatty acids and their esters have been separated by reversed-phase thin-layer chromatography with three mobile phases. The RM values of the compounds have been correlated with the numerical values of topological indexes, with the electrotopological states of the atoms attached to the carboxyl group of the compounds, with the number of hydrogen-bond donors (#HD), with the molecular weights ( MW ) of the compounds, and with the dipole moments (µ mph ) of the mobile phases. The most accurate prediction of the RM values of the acids and esters, for all the mobile phases investigated, was achieved by use of four-parameter equations relating the dipole moments of the mobile phases to three other parameters.