Back Picture: Determination of Potential Scaffolds for Human Choline Kinase α1 by Chemical Deconvolution Studies (ChemBioChem 11/2013)
María Sahún‐Roncero, Belén Rubio‐Ruíz, Ana Conejo‐García, Adrián Velázquez‐Campoy, Antonio Entrena, Ramón Hurtado‐Guerrero · ChemBioChem · 2013
The back cover picture shows the the binding modes of a new CHOKa1 inhibitor. Using a chemical deconvolution approach based on the crystal structures of CHOKa1/1 and CHOKa1/2, A. Entrena, R. Hurtado-Guerrero et al. have shown (p. 1291 ff.) that adenine and 1-benzyl-4-(dimethylamino)pyridinium are the most efficient fragments in the molecules and that CHOKa1 is very flexible, adopting local conformational changes in the choline binding site.