Electronic structure and hypolipidemic activity of phthalimide and related compounds. A QSAR study
MOZART NEVES RAMOS, Benício de Barros Neto · Journal of Computational Chemistry · 1990
Abstract The hypolipidemic activities of phthalimide and seven related compounds are subjected to a QSAR analysis based on results from AM1 molecular orbital calculations. Least‐squares fits show a correlation of the activities with LUMO energies and carbonyl polarities and predict enhanced activities for two new phthalimide derivatives.