Influence of Thermodynamic Parameter in Lanosterol 14.ALPHA.-Demethylase Inhibitory Activity as Antifungal Agents: A QSAR Approach
Vasanthanathan Poongavanam, Manickavasagam Lakshmi, Marianesan Arockia Babu, Sathish Gopalrao Kaskhedikar · Biological and Pharmaceutical Bulletin · 2006
A quantitative structure activity relationship, Hansch approach was applied on twenty compounds of chromene derivatives as Lanosterol 14alpha-demethylase inhibitory activity against eight fungal organisms. Various physicochemical descriptors and reported minimum inhibitory concentration values of different fungal organisms were used as independent variables and dependent variable respectively. The best models for eight different fungal organisms were first validated by leave-one-out cross validation procedure. It was revealed that thermodynamic parameters were found to have overall significant correlationship with anti fungal activity and these studies provide an insight to design new molecules.