A Surprising Solid-Phase Effect: Development of a Recyclable “Traceless” Linker System for Reactions on Solid Support
Stefan Bräse, Dieter Enders, Johannes Köbberling, Frank Avemaria · Angewandte Chemie International Edition · 1998
Triazenes as "traceless" linkers for solid-phase synthesis have been utilized for the attachment of arenes to a solid support and yield the corresponding products after various organometallic reactions (Heck reaction and asymmetric dihydroxylation, see the reaction scheme) and cycloadditions (Diels-Alder reaction). The triazene linker is distinguished by its accessibility, thermal robustness, and capability to undergo regeneration.