α‐Naphthylaminopropan‐2‐ol Derivatives as BACE1 Inhibitors
Valentina Asso, Elisa Ghilardi, Simone Bertini, Maria Digiacomo, Carlotta Granchi, Filippo Minutolo, Simona Rapposelli, Andrea Bortolato, Stefano Moro, Marco Macchia · ChemMedChem · 2008
Fast and healthy (molecular) weight loss! A relatively large BACE1 inhibitor containing a hydroxyethylamine aspartyl protease inhibitor motif was identified by high-throughput screening, and has inspired the design of new “lighter”, biologically active derivatives, representing a promising new class anti-Alzheimer's drugs.