Mining drug–disease relationships as a complement to medical genetics‐based drug repositioning: Where a recommendation system meets genome‐wide association studies
H Wang, Quanquan Gu, J Wei, Zhiwei Cao, Q Liu · Clinical Pharmacology & Therapeutics · 2015
A novel recommendation-based drug repositioning strategy is presented to simultaneously determine novel drug indications and side effects in one integrated framework. This strategy provides a complementary method to medical genetics-based drug repositioning, which reduces the occurrence of false positives in medical genetics-based drug repositioning, resulting in a ranked list of new candidate indications and/or side effects with different confidence levels. Several new drug indications and side effects are reported with high prediction confidences.