Parascending: a safer alternative to hang gliding.
A J Macaulay, Peter G.F. Nixon · BMJ · 1977
A zero value had been found in all cases before tamoxifen treatment, but after tamoxifen the index regularly increased to values between 10 and 300%, reaching 500% or more in four cases and 800 in one.This effect has not previously been described in humans.The smears returned to an atrophic pattern within two months after tamoxifen withdrawal.Overall, 32 % of the patients responded favourably to tamoxifen, showing an objective tumour regression.No sure relationship has been evidenced between the post-treatment rise in KPI and the response of cancer to tamoxifen treatment.As in some animal models, the drug seems to have an oestrogen-like effect on the vaginal epithelium.It is still not clear whether the tumour may also react to tamoxifen as if it was an oestrogen.