The Hydrolytic Rate of Barbituric Acid and the Extrathermodynamic Relationship
SHOZO ASADA, Midori Yamamoto, Jujiro Nishijo · Bulletin of the Chemical Society of Japan · 1980
Abstract The enthalpy-entropy relationship of activation was subjected to discussion in connection with the alkaline hydrolysis of 10 barbituric acids. The extrathermodynamic linear equation was derived by using several parameters; the dissociation constant (pK), the 13C shift value [δc(5)] at the 5-position of the ring, and/ or the molecular connectivity index (χ).