Sensitivity of integral computer-aided detection with full-field digital mammography for detection of breast cancer according to different histopathological tumor types and appearances
Katja Pinker, Nicholas Perry, Sue Milner, Kefah Mokbel, Stephen William Duffy · Breast Cancer Research · 2010
A TP mark was observed on 319 out of the 360 cancers (89%). Calcifications were significantly ( P <0.001) more likely to be marked than masses, 163/164 (99%) compared with 244/296 (82%). The probability of a mass TP mark was significantly related to histological type ( P <0.001), with sensitivity being greatest for IDC at 76% (167/221) compared with 67% (38/57) for ILC, 31% (16/51) for DCIS and 74% (23/31) for other types. The probability of a calcification TP mark was also significantly related to histological type, with sensitivity being greatest for DCIS at 75% (38/51), compared with 43% (96/221) for IDC, 33% (19/57) for ILC and 32% (10/31) for other types. CAD prompted the significant majority of radiological abnormalities related to cancers and was most accurate for detection of calcification and DCIS, less so for mass lesions and ILC.