Chiral bicyclic [2.2.2] octadiene ligands for Rh-catalysed catalytic asymmetric conjugate additions to acyclic enones: a quantitative structure–property relationship
Yunfei Luo, Neil G. Berry, Andrew J. Carnell · Chemical Communications · 2012
A series of chiral bicyclic [2.2.2]diene ligands gave variable ee values for Rh-catalysed asymmetric conjugate addition to an acyclic enone. The interplay between electronic and steric effects was captured in a robust predictive quantitative structure-property relationship (QSPR) model for enantioselectivity.