Variable latencies of noisy signals: Estimation and testing in brain potential data
Pham Dinh Tuan, Joachim Möcks, Walter Köhler, Théo Gasser · Biometrika · 1987
The electric response of the brain related to some event, i.e. stimulus, is usually estimated by repeated stimulation and subsequent averaging of the activity recorded time-locked to the stimulus. The present paper deals with the model that the single responses may have varying latency, i.e. arrival time, after stimulus onset. For estimating the single latencies, a maximum likelihood approach employing iterative Fisher-scoring is developed. Further a statistic for testing on the presence of latency variation is derived. Simulations and real data applications are discussed.