A Chemogenomic Approach to Discovering Target‐Selective Drugs
William P. Janzen, C. Nicholas Hodge · Chemical Biology & Drug Design · 2005
An approach is described for identifying scaffolds with predefined selectivity profiles directly from a high-quality high-throughput screening data set, and monitoring that selectivity profile throughout the drug discovery process. This approach results in reduced drug development timelines from "hit" to "lead" stage, and should reduce liabilities for a molecule advancing through the development process.