OBSERVATIONS ON THE APPLICATION OF THE ROBBINS‐MONRO PROCESS TO SEQUENTIAL TOXICITY ASSAYS
David F. Hawkins · British Journal of Pharmacology and Chemotherapy · 1964
The Robbins-Monro process is a sequential procedure which can be used in toxicity assays. The principal advantages are maximal economy of drug and animals and immediate availability of an estimate of the LD50 at any stage in the assay. The disadvantages are the need to wait for the outcome in each group of animals before testing the next group and the lack of an accurate method for determining confidence limits. Some practical details of the application of the method are given.