A Model of Colonic Crypts using SBML Spatial
Daniele Ramazzotti, Carlo Maj, Marco Antoniotti · Electronic Proceedings in Theoretical Computer Science · 2013
The Spatial Processes package enables an explicit definition of a spatial environment on top of the normal dynamic modeling SBML capabilities. The possibility of an explicit representation of spatial dynamics increases the representation power of SBML. In this work we used those new SBML features to define an extensive model of colonic crypts composed of the main cellular types (from stem cells to fully differentiated cells), alongside their spatial dynamics.