A Map of Alzheimer’s Disease–Signaling Pathways: A Hope for Drug Target Discovery
Soichi Ogishima, Satoshi Mizuno, Masataka Kikuchi, Akinori Miyashita, Ryozo Kuwano, Hajime Tanaka, Jun Nakaya · Clinical Pharmacology & Therapeutics · 2013
Alzheimer's disease (AD) is a complex neurodegenerative condition, and its drug therapy is challenging. To inform AD drug discovery, we developed the “AlzPathway,” a prototype of a comprehensive map of AD-related signaling pathways, from information obtained through studies in the public domain. The AlzPathway provides an integrated platform for systems analyses of AD-signaling pathways and networks. Clinical Pharmacology & Therapeutics (2013); 93 5, 399–401. doi:10.1038/clpt.2013.37