Principal dynamic mode analysis of hippocampal neuronal networks
Eunji Kang, Peter Louis Carlen, Berj L. Bardakjian · BMC Neuroscience · 2007
Principal dynamic modes (PDMs) are a primary set of basis functions that describes the dynamics of the system. By using PDMs, we attempt to show the differences between the dynamics of the epileptic neuronal network and the normal (non-epileptic) neuronal network. The input-output data required for training and modeling was acquired from acute slices of the rat hippocampus. A seizure-like state was induced by perfusion with low Mg artificial cerebrospinal fluid. Gaussian white-noise (GWN) was applied as input to CA3 pyramidal neuron and the output was measured from the same CA3 pyramidal neuron. PDMs were computed using the Laguerre expansion technique.