Discovery and validation of the antimetastatic activity of citalopram in colorectal cancer
Murat Iskar, Peer Bork, Vera van Noort · Molecular & Cellular Oncology · 2015
Inverse gene expression profiling was recently shown to help drug repositioning. We showed that this approach works best for cancer and predicted novel drug candidates that may reduce metastasis in colorectal cancer. Antimetastatic activity of our predicted candidate, citalopram, was validated in an orthotopic mouse model of metastatic colorectal cancer.