Protein NMR-Based Screening in Drug Discovery
Edward R. Zartler, Michael B. Shapiro · Current Pharmaceutical Design · 2006
Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution. Keywords: NMR, Protein labeling, Chemical Shift Perturbtation, RAMPED-UP