Effect of forphenicinol on the production of Ia-positive macrophages in mice with or without L1210 leukemia and on the growth of L1210 in immunized mice.
Akira Okura, Hiroharu Arakawa, Tomoko Yoshinari, KYOZO NAITO, Masaaki Ishizuka, TOMIO TAKEUCHI, HAMAO UMEZAWA · The Journal of Antibiotics · 1986
Oral administration of forphenicinol, S-2-(3-hydroxy-4-hydroxymethylphenyl)glycine, increased the production of Ia-positive peritoneal macrophages in healthy mice. Moreover, forphenicinol increased Ia-positive macrophages in L1210-bearing mice. Though forphenicinol was ineffective against mouse leukemia L1210 when administered alone, in combination with L1210 vaccine it prolonged the survival time of L1210-bearing mice and the increase in the number of Ia-positive macrophages in peritoneal cavity coincided with the prolongation of the survival time. These results suggest that the initial action of forphenicinol is the preferential induction of Ia-positive macrophages, which play a role in the subsequent activation of various immune responses including macrophage activation.