3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: A Promising Building Block for Medicinal Chemistry
Aleksandr Denisenko, Andrey P. Mityuk, Oleksandr O. Grygorenko, Dmitriy M. Volochnyuk, Олег В. Шишкин, Andrey A. Tolmachev, Pavel K. Mykhailiuk · Organic Letters · 2010
An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound is shown to be a promising building block for further selective derivatization of the cyclobutane ring providing novel conformationally restricted piperidine derivatives.