Using formal concept analysis for mining hyomethylated genes among breast cancer tumors subtypes
Islam Ibrahim Amin, Samar Kamal Kassim, Aboul Ella Hassanien, Hesham Ahmed Hefny · 2013
Hypomethylation of DNA have been associated with cancer in several investigations. Hypomethylated of CPG islands associated with promoters can affect the expression of genes to be more expressed. The Illumina GoldenGate Methylation Cancer Panel I can measure DNA methylation at 1505 CpG loci of 806 cancer related genes. A powerful tools to analysis the DNA methylation data are needed. In this paper, formal concept analysis (FCA) is used as data mining tool for mining the hypomethylated genes among breast cancer subtypes, by building formal concepts with significant hypomethylated genes for each breast cancer subtypes. The concept lattice is constructed based on a formal context which is composed of formal concepts. This lattice reflects the biological relationships among breast cancer subtypes.