Similarity Based Virtual Screening: A Tool for Targeted Library Design
Joni Alvesalo, Antti Siiskonen, Mikko J. Vainio, Päivi Tammela, Pia Maarit Vuorela · Journal of Medicinal Chemistry · 2006
High throughput screening drug discovery utilizes large and expensive compound libraries. As an alternative, a smaller targeted library can be constructed with the aid of the 3D structure of the target molecule. We used the X-ray crystal structure of a protein homologous to the selected target in creation of a small focused library and evaluated inhibition potential of this library against Chlamydia pneumoniae, a common pathogen recently linked to atherosclerosis and risk of myocardial infarction.