QSAR Study of Anticonvulsant Negative Allosteric Modulators of the AMPA Receptor
Antonio Macchiarulo, Laura De Luca, Gabriele Costantino, Maria Letizia Barreca, Rosaria Gitto, Roberto Pellicciari, Alba Chimirri · Journal of Medicinal Chemistry · 2004
A quantitative structure-activity relationship (QSAR) study was performed on a set of 49 negative allosteric modulators of AMPA receptor, acting as anticonvulsant agents, using multiple linear regression. The predictive ability of the resulting model was evaluated against a set of 12 compounds; the results showed good statistics in regression and revealed high correlation between anticonvulsant activity and some electrotopological descriptors.