Predictions of the antimalarial activity of arylamidinoureas
Peter J. Goodford, Frank E. A. Norrington, W. H. G. Richards, Leslie Percy Walls · British Journal of Pharmacology · 1973
1. Regression equations were calculated relating the observed antimalarial potencies of arylamidinoureas to their predicted physicochemical properties.2. A two-parameter equation was used to forecast the antimalarial activity of more arylamidinoureas.3. Thirteen compounds of the predicted type were synthesized, and their observed antimalarial potencies compared with the forecasts.