Guilt by association as a search principle
Limsoon Wong · 2008
The exploitation of fundamental invariants is among the most elegant solutions to many computational problems in a wide variety of domains. One of the more powerful approaches to exploit invariants is the principle of "guilt by association". In particular, the principle of guilt by association is the foundation of remote homolog detection, protein function prediction, disease subtype diagnosis, treatment plan prognosis, and other challenges in computational biology. The principle suggests that two entities are in a specific relationship if they exhibit invariant properties underlying that relationship. For example, a protein is predicted to have a particular biological function if it exhibits the underlying invariant properties of that functional group---viz., guilty by association to other members of that functional group through the shared invariant properties.