Histopathology and MR image fusion of the prostate
Hyun Hee Jo, Julip Jung, Yu-Jin Jang, Helen Hong, Hak Jong Lee · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · 2008
We propose a method for combining histopathology image with MR image of the prostate by using image correction and nonrigid registration. Our method consists of four steps. First, two or four tissue sections of the prostate in histopathology image are combined to produce a single prostate image by stitching. Second, the intensity of prostate bleeding area on T2-weighted MR image is substituted for that on T1-weighted MR image. Our intensity correction prevents a mistake which a prostate bleeding is considered as a tumor on T2-weighted MR image. Third, rough and fine registration is performed to find the best match for pixel overlap between histopathology and MR images. Then the result of rigid registration is deformed by the TPS warping. Finally, aligned images are visualized by the intensity intermixing. Experimental results show that the prostate tumor lesion can be properly located and clearly visualized within MR images for tissue characterization comparison.