Co-registration Framework for Histology-registration-based Validation of Fused Multimodality Prostate Cancer Imaging
Eli Gibson, Cathie Crukley, Vaishali Karnik, Mena Gaed, José A. Gómez, Madeleine Moussa, Joseph L. Chin, Glenn S. Bauman, Aaron Fenster, Aaron D. Ward · 2011
The correlation of multiple in vivo imaging modalities with graded whole-mount histology ideally requires co-registration with appropriately quantified accuracy. This work presents a framework for the co-registration of multiple in vivo prostate images with histology as a composition of pair wise registrations. This work also proposes a methodology for the measurement of the accuracy of these registrations based on a composition of target registration errors calculated from homologous landmarks in registered pairs of images. Preliminary results from the implementation of components of the framework are reported.