Thermodynamic treatment of ligand‐receptor interactions
Vito Di Noto, Lisa Dalla Via, Antonio Toninello, MAURIZIO VIDALI · Macromolecular Theory and Simulations · 1996
Abstract This work reports the development of a physico‐chemical model for ligand‐receptor interactions. It considers receptors having groups of different binding sites in equilibrium and far from equilibrium where each of these may have multiple occupancies. The obtained results under appropriate simplifications give the well known Scatchard, Hill and Adair relations and provide a very interesting tool for studying receptor‐ligand phenomena and for determining the related parameters and interaction energies.