Cell line specific method based on functional modules for drug sensitivity prediction
Woochang Hwang, Jaejoon Chio, Mijin Kwon, Doheon Lee · 2015
It is necessary to predict the efficacy of individual drugs on patients to realize personalized medicine. Testing drugs on patients in clinical trial is the only way to evaluate the efficacy of drugs. The approach is labor intensive and requires overwhelming costs and a number of experiments. Therefore, preclinical model system has been intensively investigated for predicting the efficacy of drugs. Current computational drug sensitivity prediction [1-2] approaches used known genes, known pathways or general biological network module as their prediction features. Therefore, they missed indirect effector or the effects from tissue-specific interactions.