On the synthesis of heterocyclic dendrons
Enrique Dı́ez-Barra, Joaquín Calixto García-Martínez, Javier Guerra, Valentı́n Hornillos, Sonia Merino, Riánsares del Rey, René Ignacio Rodríguez-Curiel, Julián Rodríguez‐López, Prado Sánchez‐Verdú, Juan Tejeda, Juan Tolosa · ARKIVOC · 2002
The synthesis of dendrons 1 -7 bearing azole (pyrazole, imidazole and 1,2,4-triazole) moieties is described.The synthesis of these compounds was carried out using different approaches: functionalisation of the methylene bridge of bispirazol-1-ylmethane derivates; double Michael addition of 1,2,4-triazole to methyl propiolate, nucleophilic substitution of halide from the corresponding 2,6-dichloro-4-methylpyridine or 1,3-bis(bromomethyl)benzene derivatives, and nucleophilic substitution on p-hydroxybenzaldehyde dimethylacetal.Schotten-Baumann reaction with 1,3,5-trischlorocarbonylbenzene and Sonogashira coupling with 1,3,5-triethynylbenzene were used for the synthesis of G0-dendrimers.