Differentiating Serine and Cysteine Protease Mechanisms by New Covalent QSAR Descriptors
Michael Shokhen, Tamar Traube, S. Vijayakumar, Michal Hirsch, Neta Uritsky, Amnon Albeck · ChemBioChem · 2011
QSAR—A mechanistic tool for proteases: New covalent QSAR descriptors for enzyme inhibition, W1 and W2, serve as mechanistic tools in the study of Ser and Cys proteases, providing support to an ionic tetrahedral complex for the former and a neutral (protonated) tetrahedral complex for the latter.