Neuroprotective effects of acetylsalicylic acid in an animal model of focal brain ischemia
Naiyar Khayyam, Paaladinesh Thavendiranathan, Frederick J. Carmichael, Bart Kus, Venita Jay, WR Burnham · Neuroreport · 1999
Recent studies have shown neuroprotective effects of acetylsalicylic acid (ASA) in cell cultures and hippocampal slices. The present study demonstrates similar effects in a whole-animal modal of focal ischemic stroke. Focal cortical ischemia was produced in Wistar rats by ligation of the common carotid and middle cerebral arteries. Subjects were sacrificed 8 days after ligation, and infarct volume was assessed via automated densitometry. Significant reductions in infarct volume were seen with i.p. ASA doses of 15 mg/kg and above. Reductions occurred when ASA was injected 2 h or 30 min before ligation, but not when it was injected 8 or 24 h before, or 30 min after ligation.