Scaffold Hopping by “Fuzzy” Pharmacophores and its Application to RNA Targets
Yusuf Tanrıkulu, Manuel Manfred Nietert, Ute Scheffer, Ewgenij Proschak, Kristina Grabowski, Petra Schneider, Markus Weidlich, Michael Karas, Michael Göbel, Gisbert Schneider · ChemBioChem · 2007
Don't look sharp, look fuzzy. A technique for “fuzzy” pharmacophore screening is presented. Two prospective applications with RNA targets were performed: virtual screening for inhibitors of the Tat-TAR RNA interaction and in vitro protein expression. The hits contain alternative scaffolds and were found through a fuzzy pharmacophore model (see figure) of ligand binding poses.