Scaffold diversity of natural products: inspiration for combinatorial library design
Kristina Grabowski, Karl‐Heinz Baringhaus, Gisbert Schneider · Natural Product Reports · 2008
Natural products contain scaffold structures that can be systematically exploited for the design of combinatorial compound libraries with druglike properties. We review approaches for scaffold identification, and compare properties and pharmacophoric features of drugs and natural products. In particular, an application of the self-organizing map technique is presented for natural product-derived compound and library design.