Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population
Seppo Helisalmi, Bart Dermaut, Mikko O. Hiltunen, A. Mannermaa, Marleen Van den Broeck, Maarit Lehtovirta, A M Koivisto, Susan Iivonen, Marc Cruts, Hilkka S. Soininen, Christine Van Broeckhoven · Neurology · 2004
The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD patients without the APOE epsilon4 allele.