An Appraisal of Phenylbutazone Suppositories
C.F. Hawkins, H. T. Fawns · BMJ · 1959
BRIOnJR1.AL is 5%.An advantage of this method is that the risk of making errors of this kind is stated (Bross, 1952).In both of the methods described the number of patients needed to decide the outcome was less than would be needed, on the average, with the equivalent fixed-sample-size test.This economy in cases is a valuable feature of sequential methods.The small numbers were also determined by the comparatively high proportion of preferences required for the new drug before we were willing to recommend it.Because the procedure is so simple both methods are well suited to the trial of new drugs in a busy out-patient clinic or admission ward.Suitable patients are observed as they occur in the course of the daily work; the data