Image-guided prostate sectioning supporting registration of graded cancerous foci from digital histopathology images to in vivo MRI: an interactive 3D visualization tool
E. Gibson, Aaron Fenster, Cathie Crukley, Charles A. McKenzie, José A. Gómez, Madeleine Moussa, Glenn S. Bauman, Aaron D. Ward · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · 2011
Personalized treatment of prostate cancer would be enhanced by an assessment of cancer stage and grade from imaging, the validation of which requires the accurate co-registration of in vivo images with a gold standard for stage and grade established by histopathology. We present a visualization tool supporting an image-guided approach enabling the acquisition of histopathology images parallel to the in vivo imaging planes, simplifying this registration. This tool decreases imaging-to-specimen landmark alignment error by 62%, and decreases the time required to mark the slicing plane on the specimen by 47%. Preliminary results from our method demonstrate the alignment of regions suspicious for cancer on T2w MRI with confirmed cancer foci on histopathology, and we calculate a sub-millimeter in-plane target registration error.