GOAssay: from Gene Ontology to Assays IDentifiers - Towards Automatic Functional Annotation of PubChem BioAssays
Rajarshi Guha, Julien Gobeill, Patrick Ruch · Nature Precedings · 2009
Abstract OBJECTIVES: We report on a experiment to functionally annotate PubChem assays using the Gene Ontology Categorizer (GOCat). METHODS and MATERIALS: The assays are processed to filter out non functional information, then the textual content is sent to the categorizer, which provide a ranked list of GO descriptors based on a GOA-learned association model. RESULTS: The GO descriptors are regarded as irrelevant for only 18% of the assays. CONCLUSION: Semantic enrichment of PubChem assays with functional genomics categories seems effective at least to navigate PubChem assays. AVAILABILITIES: the database is hosted by the University of Indiana at "http://goassay.rguha.net/index.html":http://goassay.rguha.net/index.html; the GO categorizer interface and service is available at the University of Geneva "http://eagl.unige.ch/EAGLi/":http://eagl.unige.ch/EAGLi/.