Inside Cover: Docking Studies of Structurally Diverse Antimalarial Drugs Targeting PfATP6: No Correlation between in silico Binding Affinity and in vitro Antimalarial Activity. (ChemMedChem 9/2009)
Fatima El Garah, Jean‐Luc Stigliani, F. Cosledan, Bernard Meunier, Anne Robert · ChemMedChem · 2009
The inside cover picture shows the calculated binding modes of antimalarial drugs in the active site of the Plasmodium falciparum calcium ATPase (PfATP6). Docking studies of peroxide-containing antimalarial agents indicate that highly potent compounds have the same affinity for PfATP6 as their biologically inactive derivatives, making the role of PfATP6 inhibition in the mechanism of action of artemisinin doubtful. For more details, see the Full Paper by A. Robert et al. on p. 1469 ff.