Needs for an Expanded Ontology-Based Classification of Adverse Drug Reactions and Related Mechanisms
P E Zhichkin, Brian Athey, Mark Avigan, D. R. Abernethy · Clinical Pharmacology & Therapeutics · 2012
The growing significance of bioinformatics and systems biology in drug safety research requires a system of adverse-event classification that goes beyond a simple vocabulary. This opinion piece outlines the need for development of an ontology-based framework of describing adverse drug reactions (ADRs) and describes the potential applications for such a framework. Clinical Pharmacology & Therapeutics (2012); 91 6, 963–965. doi:10.1038/clpt.2012.41