Three-Dimensional Protein Structure Prediction for CD36
Wei Ye Tao, Lai You Wang, Guo Quan Huang, Man Luo · Advanced materials research · 2014
CD36 is a class B scavenger receptor, which is on the surface of many cells such as platelets, macrophages, endothelial and smooth muscle cells. CD36 has been shown to play a critical role in the development of atherosclerosis by its capacity to adhere oxidized low density lipoproteins (OxLDL). It’s very valuable to find out the antagonists for CD36, but the three-dimensional protein structure of CD36 has not been determined and there are no template structures in the PDB library, which greatly prevents the antagonist discovery from structure-based drug discovery. The aim of the present study is to predict the three-dimensional structure using computational methods by I-TASSER.