Inside Cover: Organocatalytic Enantioselective Morita–Baylis–Hillman Reaction of Maleimides with Isatins (Asian J. Org. Chem. 7/2013)
Pankaj Chauhan, Swapandeep Singh Chimni · Asian Journal of Organic Chemistry · 2013
Organocatalysis Maleimides are known to be very good electrophiles, dienophiles, and dipolarophiles. In their Full Paper on page 586 ff., Pankaj Chauhan and Swapandeep Singh Chimni demonstrate that maleimide derivatives can be used as nucleophilic partners in an efficient organocatalytic Morita-Baylis-Hillman reaction with isatins catalyzed by β-isocupreidine. This reaction gives chiral 3-substituted-3-hydroxyoxindoles in high yield and excellent enantioselectivity.